The Homeostasis Regulatory Systems page revealed that most signs and symptoms are due to allostasis of different homeostasis regulatory systems. As noted, homeostasis literally means “similar state”, in which body function are ideal. When a system is out of balance it is in allostasis, which means “different state” – things are not ideal. And most signs and symptoms are due to allostasis many different homeostasis regulatory systems.
For example, fatigue may be caused by allostasis in any one of the of the following homeostasis regulatory systems:
Formulated by Dr Joseph J Collins RN ND
Signs and Symptoms
Hypothalamic-Pituitary-Adrenocortical (HPA) axis
Sympatho-Adrenomedullary System (SAS)
Hypothalamic-Pituitary-Gonadal (HPG) axis
Hypothalamic-Pituitary-Thyroid (HPT) axis
Neuro-Endocrine-Immune (NEI) system
Glucose-Insulin System (GIS)
Brain Monoaminergic System (BMS)
Renin-Angiotensin-Aldosterone System (RAAS)
Hepatic Detoxification System (HDS)
Cellular Signaling Systems (CSS)
REDuction-OXidation System (REDOX)
Ghrelin-Leptin-Adiponectin System (GLAS)
Yes, fatigue is a symptom that occurs with allostasis in any one of the homeostasis regulatory systems. As noted, one of the first things that experienced clinicians realize when they are treating patients with fatigue disorders is that it’s not just adrenal fatigue.

In fact, the symptoms that have been associated with adrenal fatigue are common in most chronic conditions, as well as many acute conditions in which the body cannot adapt to the acute stressor. What we have been seeing is multiple systems being affected by stress. This is what Dr Hans Selye called generalized adaption syndrome as noted in the page discussing adrenal fatigue.

Some of the many symptoms associated with adrenal fatigue and generalized adaption syndrome include:
tire easily
decreased stamina
decreased strength
episodes of high energy (hypomanic)
poor memory
obsessive thoughts
depressed thoughts
“brain fog” / dyscognia
sensory hypersensitivity
racing heart
shallower breaths
changes in appetite
cravings salt
sugar craving
alternating diarrhea/constipation
hypothyroid symptoms
hypogonadal symptoms
decreased libido / sexual dysfunction
circadian dysfunction
sleep disorders
allergen sensitivity
chemical sensitivity
increased infections

Multiple Causes of Symptoms
While we are often tempted to try to find a “single cause” for a particular sign or symptom, in truth all signs and symptoms have multiple causes. Just as fatigue has multiple causes, so do other symptoms. This is because the Homeostasis Regulatory Systems have very dynamic interactions.

Introduction to Adaptogenic Herbs

Since most signs and symptoms are due to allostasis of different homeostasis regulatory systems, ideal health must be restored to all homeostasis regulatory systems. These multiple homeostasis regulatory systems which have become imbalanced can be restored to equilibrium by using specific herbs that help the body adapt to stress. These herbs are appropriately named “adaptogens” or “adaptogenic herbs”. Adaptogenic herbs create or generate the ability to adapt to stress. Thankfully, most adaptogens will be beneficial to more than one homeostasis regulatory system.

Learn more about adaptogenic herbs.

Signs and Symptoms of Adrenal Fatigue  & Allostasis
A Hormone Specific Formulation
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